Aritmologia in Campania

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Left Atrial Appendage Occlusion - Opportunities and Challenges

David R. Holmes, JR, MD,* Dhanunjaya R. Lakkireddy, MD,y Richard P. Whitlock, MD, PHD,z Ron Waksman, MD,x Michael J. Mack, MD

Stroke prevention in patients with atrial fibrillation is a growing clinical dilemma as the incidence of the arrhythmia
increases and risk profiles worsen. Strategies in patients with nonvalvular atrial fibrillation have included
anticoagulation with a variety of drugs. Knowledge that stroke in this setting typically results from thrombus in the
left atrial appendage has led to the development of mechanical approaches, both catheter-based and surgical, to
occlude that structure. Such a device, if it were safe and effective, might avoid the need for anticoagulation and
prevent stroke in the large number of patients who are currently not treated with anticoagulants. Regulatory
approval has been difficult due to trial design challenges, balance of the risk-benefit ratio, specific patient
populations studied, selection of treatment in the control group, and specific endpoints and statistical analyses
selected. Accumulating data from randomized trials and registries with longer-term follow-up continues to support
a role for left atrial appendage exclusion from the central circulation as an alternative to anticoagulation in carefullyselected
patient populations. (J Am Coll Cardiol 2014;63:291–8) ª 2014 by the American College of Cardiology

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